Difference Between Acid and Shrooms (With Table)

Acid and shrooms are the two most used drugs for treating anxiety and PTSD. They get used for the same purpose, but they have different effects on the body. So, everyone should not take them with the consent of a doctor. 

It is important to know the scientific difference between the two drugs acid (lysergic acid diethylamide) and shrooms (psilocybe cubensis) for protecting yourself and your family.

Acid vs Shroom

The main difference between the acid and the shroom is that the acid (lysergic acid diethylamide) contains lysergic acid that can be obtained from the fungus that grows on grain. It is purely synthetic. On the other hand, shrooms (psilocybe cubensis) are a mushroom that contains the natural compound that is psilocybin. 

The acid (lysergic acid diethylamide)  is a synthetic drug that contains lysergic acid, which can be found on fungus. This drug is commonly taken as a liquid or as a pill. It can also be taken directly in the mouth through a piece of paper soaked with the drug.

The shrooms (psilocybe cubensis) contains the nature made psychedelic compound psilocybin. The psilocybin can be found in some parts of South America, the United States and Mexico. This drug can be taken with some other natural food, such as mixing with tea or juice. Some people also take this drug as dried and raw.

Comparison Table Between Acid and Shroom

OriginIt gets invented in 1938. A Swiss Scientist, whose name was Albert Hoffman, has first synthesized this drug.People have been using it for a long time. And it is casually found in the various parts of the United States, Mexico, and South America.
SourceThis drug gets made from a chemical compound known as lysergic acid. This lysergic acid gets found on a fungus, which grows on grain. This drug gets obtained from psychedelic mushrooms which contain a compound known as psilocybin. It is estimated that psychedelic mushrooms have more than two hundred species.
NatureIt is a man-made drug, which has no odour, no taste and is clear.This drug is synthetic and is very bitter. That is the reason why people take it with some sweet drink.
Long-lasting effect The long-lasting effect of the acid is up to 20 hours.The long-lasting effect of shrooms is between four to six hours.
AntidepressantThis drug gets the potential to treat anxiety, PTSD, obsessive-compulsive disorder, depression, and addiction.This drug can treat anxiety, addiction, obsessive-compulsive disorder, and PTSD.
EffectIt affects the brain.It affects the brain.
BrainA brain, after taking this pill works like the brain of a child.A brain, after taking this pill works like it is dreaming.

What is Acid?

Acid means LSD. This drug is used for treating anxiety and addiction. It was invented in 1938 by Swiss scientist Albert Hoffman, who himself took the drug and went for bike riding. It is a purely synthetic drug. 

LSD stimulates the synthetic nervous system of the body, which in turn increases the blood sugar level and increases the body temperature of the consumer. As these activities happen, the brain confuses them with the activity caused by serotonin and sends the signal to the brain’s synaptic cleft. When LSD reaches there, the serotonin receptor proteins start making bonds with the LSD. 

A team of scientists discovered that when serotonin, the drug (LSD), reaches the brain, the pattern of network communication, blood flow, and electrical activity changes. When the barrier between the information-carrying regions and the visual cortex breaks down, the consumer of the drug completely gets into the hallucination.

What is Shroom?

A mushroom is also an antidepressant drug used for treating anxiety and addiction. When someone takes the shrooms (psilocybin), the psilocybin enters the brain through the blood. Where it starts forming bonds with the receptors of serotonin. 

The receptor gets activated by forming a bond with the psilocybin. This causes the visual cortex to become more vulnerable to the visual signal. The effect of psilocybin can not be seen till 15 minutes after taking the pill, which means the consumer will not experience any symptom of hallucination up to an hour after taking the drug. 

The liver takes the time between the consumption of the pill and the hallucination to break down the psilocybin into a compound known as psilocin. The ability of the brain to respond to negative things gets weekends during the process. The compound psilocybin, in the words of scientists, causes ‘ego dissolution. This means that the psilocybin makes the frontoinsular cortex and the anterior cingulate cortex less responsive. 

Main Differences Between Acid and Shroom

  1. LSD (acid) is a synthetic drug. On the other hand, shroom (magic mushroom) is a natural drug.
  2. The effect of LSD starts immediately. On the other hand, the effect of shrooms does not start between 15 minutes to 1 hour, after taking the drug.
  3. The effect of LSD lasts up to 20 hours. On the other hand, the effect of shroom lasts up to six hours.
  4. The serotonin folds over the drug like a lid which does not end the effect of it on consumers until the molecule pops off the receptor. On the other hand, there is no such thing as shrooms.
  5. The acid causes the brain to become hyperconnected. On the other hand, The shroom causes a slight loss of identity and heightened emotions.
  6. The acid contain a compound known as lysergic acid. On the other hand, the Shrooms release a compound known as psilocybin, which inside the body, breaks down in psilocin.


The work of both the drugs (acid and shroom) is releasing serotonin. Both of these are used in treating a person suffering from anxiety, addiction, depression, and other mental diseases. 

The acid (LSD) and the shroom (Sweet mushroom) are the drugs that contain a  kind of chemical, which can make bonds with the serotonin receptor part of the brain.


  1. https://www.sciencedirect.com/science/article/pii/B9780128156070000332
  2. https://n.neurology.org/content/66/12/1920.short